Healthcare Clinical Screening Glossary

A premarket submission demonstrating that a medical device is substantially equivalent to a legally marketed predicate device. A 510(k) is a premarket submission to the U.S. Food and Drug Administration required for most Class II medical devices. It demonstrates that the new device is substantially equivalent in intended use and technological characteristics to an already legally marketed device. FDA device establishment registration validates that the device meets FDA safety and effectiveness standards. digitalhumanOS™ by Scienza Health is FDA-registered with the FDA for multimodal clinical screening of cognitive, neurological, and behavioral health conditions.

Basic self-care tasks—bathing, dressing, eating, transferring, toileting, and continence—used to assess functional status. Activities of Daily Living (ADL) are the fundamental self-care tasks that indicate a person’s functional independence. ADL assessment is a core component of care planning in post-acute and long-term care facilities and is required by CMS for MDS reporting. Decline in ADL performance often correlates with cognitive or neurological deterioration. By detecting early cognitive and neurological changes through speech biomarker screening, GIA® by Scienza Health can help clinicians anticipate ADL decline before it manifests in observable functional limitations.

A standardized clinician-rated scale for assessing tardive dyskinesia and other involuntary movement disorders. The Abnormal Involuntary Movement Scale (AIMS) evaluates involuntary movements across facial, oral, extremity, and trunk regions. It is the standard tool for monitoring tardive dyskinesia (TD) in patients taking antipsychotic medications. AIMS requires trained clinician observation and takes 10–15 minutes. CMS F-Tag 605 mandates monitoring for patients on psychotropic medications. GIA® by Scienza Health can screen for movement-related indicators through vocal tremor analysis and facial micro-expression detection, supporting facilities in meeting F-Tag 605 compliance requirements.

A residential care setting providing personal care assistance and health monitoring for adults who need help with daily activities but not 24-hour nursing. Assisted living facilities provide housing, meals, personal care assistance, and health monitoring for adults who need support with activities of daily living but do not require the continuous skilled nursing care provided in SNFs. Assisted living residents are at elevated risk for undetected cognitive decline, depression, and anxiety because screening protocols are less rigorous than in skilled nursing. Automated screening technology like GIA® by Scienza Health can close this gap by providing routine cognitive and behavioral health screening without requiring clinical staff.

A legally required contract between a HIPAA-covered entity and a vendor that handles protected health information on its behalf. Under HIPAA, any business associate—a vendor that creates, receives, maintains, or transmits protected health information (PHI) on behalf of a covered entity—must sign a BAA. The agreement specifies permitted uses and disclosures of PHI, requires appropriate safeguards, and establishes breach notification obligations. Healthcare facilities deploying clinical screening technology must have a BAA in place with the technology provider. Scienza Health executes BAAs with all facility partners as part of the standard deployment process.

A 100-point scale measuring functional independence across ten activities of daily living. The Barthel Index assigns weighted scores across ten ADL categories including feeding, bathing, grooming, dressing, bowel control, bladder control, toilet use, transfers, mobility, and stairs. Scores range from 0 (complete dependence) to 100 (full independence). The Barthel Index is widely used in rehabilitation and post-acute care settings to track functional recovery over time and to guide discharge planning decisions.

A brief cognitive screening tool used in nursing facilities as part of the MDS 3.0 assessment. The Brief Interview for Mental Status (BIMS) is a standardized cognitive assessment required by CMS for all residents in skilled nursing facilities. It evaluates repetition, temporal orientation, and recall through a brief patient interview. BIMS scores range from 0–15, with scores below 8 indicating severe impairment. While BIMS provides a regulatory baseline, speech biomarker technology like GIA® by Scienza Health can detect cognitive changes with greater sensitivity and across a broader range of conditions than BIMS alone.

A campus-based senior living community offering independent living, assisted living, and skilled nursing in one location. Continuing care retirement communities (CCRCs) provide a continuum of care on a single campus, allowing residents to transition between independent living, assisted living, and skilled nursing as their needs change. CCRCs serve residents across the full spectrum of cognitive and functional ability. Early screening is particularly valuable in CCRCs because it can identify cognitive changes in independent living residents before they require a higher level of care, enabling earlier intervention and potentially delaying transitions.

A clinician-scored scale that rates the severity of dementia across six cognitive and functional domains. The Clinical Dementia Rating (CDR) evaluates memory, orientation, judgment, community affairs, home and hobbies, and personal care through a semi-structured clinician interview with the patient and a reliable informant. The global CDR score ranges from 0 (no impairment) to 3 (severe dementia). CDR is considered a gold-standard staging tool but requires 30–60 minutes and expert clinician administration. Automated screening technologies like GIA® by Scienza Health can identify patients who warrant formal CDR evaluation by flagging early cognitive indicators from brief conversational encounters.

A system that provides clinicians with evidence-based information at the point of care to improve decision-making. Clinical decision support (CDS) systems present relevant clinical data, screening results, and evidence-based recommendations to clinicians when they need it most—during or immediately after a patient encounter. In the context of screening technology, CDS surfaces flagged conditions, severity scores, and suggested follow-up actions. GIA® by Scienza Health functions as a clinical decision support tool, delivering structured screening results with ICD-10 codes and clinician-ready notes directly to the patient’s EHR record.

The federal agency that administers Medicare, Medicaid, and regulatory standards for healthcare facilities.

Speech and behavioral features that reveal the mental effort required to perform a task. Cognitive load indicators are measurable signals—such as increased pause duration, reduced speech rate, filler word frequency, and simplified sentence structure—that reflect the amount of mental processing required during conversation. Elevated cognitive load during routine tasks can indicate early cognitive impairment, mild cognitive impairment (MCI), or progression of neurodegenerative conditions. GIA® by Scienza Health detects cognitive load indicators in real time during natural patient conversation, without requiring the patient to perform explicit memory or recall tasks.

A structured evaluation to detect early signs of cognitive impairment or decline. Cognitive screening identifies changes in memory, attention, executive function, and language ability before they progress to diagnosable conditions such as Alzheimer’s disease or mild cognitive impairment (MCI). Traditional methods like pen-and-paper assessments require trained staff and 15–30 minutes per patient. GIA® by Scienza Health automates cognitive screening using speech biomarker technology, reducing the process to a 40-second patient conversation with no staff involvement.

The automated extraction of clinical information from visual input such as facial expressions and body movement. Computer vision in clinical screening uses camera input to detect subtle physical indicators that may correlate with neurological or psychological conditions. These include facial micro-expressions, gaze patterns, blink rate, head tremor, and postural changes. When combined with speech biomarker analysis, computer vision adds a visual data layer that strengthens screening accuracy. GIA® by Scienza Health captures 436 visual data points per session during video-based screening encounters.

A standardized numeric code used to describe medical procedures and services for billing and reimbursement. CPT codes are maintained by the American Medical Association and are the standard billing language for healthcare services in the United States. In the context of clinical screening, relevant CPT codes include 96127 (brief emotional/behavioral assessment, $6–$10), 96116 (neurobehavioral status exam, $94–$131), and 99309 (subsequent nursing facility care, ~$100). GIA® by Scienza Health generates screening results that map directly to billable CPT codes, enabling facilities to capture reimbursement for screening services that previously went unbilled.

A lifelike, conversational virtual clinician that conducts patient screening autonomously. A Digital Human® is a photorealistic, conversationally intelligent virtual being designed to interact with patients in a natural, empathetic manner. Unlike chatbots or voice assistants, Digital Humans combine speech recognition, natural language understanding, computer vision, and clinical reasoning in real time. GIA® by Scienza Health is a Digital Human® purpose-built for clinical screening in post-acute and long-term care—she conducts the screening conversation, analyzes results, and writes them back to the EHR without requiring staff time.

The clinical intelligence operating system that powers GIA® and processes speech biomarker, voice, and visual analysis in real time. digitalhumanOS™ is the proprietary operating system developed by Scienza Health that orchestrates all clinical screening functions during a patient encounter. It processes voice analysis, computer vision, and speech biomarker extraction simultaneously, delivering structured clinical results to the clinician in under 2 minutes. digitalhumanOS™ is FDA-registered with the FDA and integrates with major EHR systems through HL7 FHIR and Direct API connections.

The connection between clinical screening technology and electronic health record systems for automated data exchange. EHR (Electronic Health Record) integration enables screening results, clinical notes, and patient data to flow automatically between clinical technology and the facility’s health record system. In post-acute and long-term care, seamless EHR integration eliminates double documentation, reduces transcription errors, and ensures screening results are immediately available for clinical decision-making. GIA® by Scienza Health integrates with PointClickCare, Epic, Cerner, MatrixCare, NextGen, and Athena through HL7 FHIR and Direct API connections.

Scienza Health’s service layer that automates the write-back of screening results, notes, and transcripts to the patient’s EHR. ERaaS™ (Electronic Records as a Service) is Scienza Health’s integration layer that ensures every screening result is automatically documented in the clinical record. ERaaS™ writes four data types to the EHR: structured screening results with ICD-10 codes, clinician-ready medical notes, full timestamped transcripts, and recorded patient video. This eliminates manual documentation, reduces clinician burden, and ensures regulatory compliance. ERaaS™ supports PointClickCare, Epic, Cerner, MatrixCare, NextGen, and Athena.

A CMS regulatory requirement mandating that nursing facilities monitor residents on psychotropic medications for adverse effects including tardive dyskinesia. F-Tag 605 (formerly F-329) requires skilled nursing facilities to ensure that residents are free from unnecessary psychotropic medications and that those on such medications are monitored for adverse effects. This includes monitoring for tardive dyskinesia (TD) and other movement disorders using tools like the AIMS assessment. Non-compliance can result in citations, fines, and increased survey scrutiny. GIA® by Scienza Health supports F-Tag 605 compliance by automating screening for TD-related indicators through vocal tremor analysis and facial micro-expression detection.

Detection of brief, involuntary facial movements that may correlate with emotional or neurological states. Facial micro-expressions are rapid, involuntary facial movements lasting 40–200 milliseconds that reveal underlying emotional or neurological activity. In clinical screening, these expressions can indicate masked depression, anxiety, pain, or motor impairment associated with movement disorders. Computer vision technology captures these expressions at frame-level precision during video-based patient encounters. GIA® by Scienza Health captures 436 visual data points per session, including facial micro-expression analysis, to complement its speech biomarker screening.

A seven-item questionnaire for screening and measuring the severity of generalized anxiety disorder. The GAD-7 assesses the frequency of anxiety symptoms over the past two weeks, producing scores from 0–21. Scores of 10 or higher suggest moderate anxiety requiring clinical evaluation. It is widely used in primary care and post-acute settings. Like the PHQ-9, the GAD-7 depends on patient self-report. GIA® by Scienza Health screens for anxiety using speech biomarker analysis at AUC 0.775 peer-reviewed accuracy, detecting vocal patterns associated with anxiety—such as increased speech rate, pitch variability, and reduced pause regularity—without requiring the patient to self-assess.

A self-report screening tool designed specifically for depression in older adult populations. The Geriatric Depression Scale (GDS) uses yes/no questions to screen for depression in older adults, available in 30-item and 15-item versions. Its simplified response format accommodates patients with mild cognitive impairment who may struggle with Likert-scale instruments. The 15-item GDS takes 5–7 minutes. While designed for older populations, the GDS still relies on self-report, which can be unreliable in patients with significant cognitive impairment or limited insight. Speech biomarker screening offers an objective alternative that does not depend on the patient’s ability to accurately self-assess.

Federal legislation that establishes national standards for protecting patient health information. HIPAA sets the standard for the protection of sensitive patient health information (PHI) in the United States. The Privacy Rule governs how PHI can be used and disclosed. The Security Rule requires administrative, physical, and technical safeguards for electronic PHI. Healthcare technology vendors must implement HIPAA-compliant data handling, encryption, access controls, and audit logging. Scienza Health maintains full HIPAA compliance across all data handling, storage, and transmission within the GIA® platform and ERaaS™ integration layer.

A modern healthcare data exchange standard that enables interoperability between clinical systems using web-based APIs. HL7 FHIR is the leading standard for exchanging healthcare information electronically. It uses RESTful APIs and standardized resource types (Patient, Observation, DiagnosticReport, etc.) to enable different healthcare systems to share data reliably. FHIR has become the preferred integration standard for CMS interoperability mandates. GIA® by Scienza Health uses HL7 FHIR to write structured screening results—including ICD-10 codes, clinician notes, and transcripts—directly to the patient’s EHR record in real time.

Clinical care services delivered in a patient’s home, including skilled nursing, therapy, and health monitoring. Home health provides clinical services—skilled nursing, physical therapy, occupational therapy, speech therapy, and medical social services—in the patient’s home. Home health patients often have limited access to in-facility screening services, creating gaps in cognitive and behavioral health monitoring. Mobile-enabled clinical screening technology allows home health clinicians to conduct automated screenings during routine visits using a smartphone or tablet, capturing speech biomarker data that would otherwise require a facility-based assessment.

Higher-order functional tasks—managing finances, medications, transportation, and housekeeping—that indicate independent living ability. Instrumental Activities of Daily Living (IADL) are more complex than basic ADLs and are sensitive to early cognitive decline. IADLs include managing finances, preparing meals, using the telephone, taking medications correctly, shopping, and housekeeping. Decline in IADLs is often the first observable sign of mild cognitive impairment. IADL assessment is part of comprehensive care planning in long-term care settings and helps determine the level of support a resident requires.

The global standard diagnostic coding system used to classify diseases, conditions, and health encounters. ICD-10 codes are used worldwide for clinical documentation, billing, epidemiology, and quality reporting. In the United States, ICD-10-CM (Clinical Modification) is required for all diagnostic coding. Relevant codes for clinical screening include Z79.899 (long-term medication use), G24.01 (tardive dyskinesia), and R25.0–R25.9 (abnormal involuntary movements). GIA® by Scienza Health automatically generates appropriate ICD-10 codes as part of its screening results and writes them directly to the patient’s EHR through ERaaS™.

A facility providing intensive rehabilitation services to patients recovering from stroke, brain injury, or other conditions. Inpatient rehabilitation facilities (IRFs) provide intensive, multidisciplinary rehabilitation for patients recovering from stroke, traumatic brain injury, spinal cord injury, hip fracture, and other conditions requiring at least three hours of therapy per day. Cognitive screening is essential in IRFs because cognitive impairment directly affects rehabilitation participation and outcomes. Automated screening using speech biomarker technology can identify cognitive barriers to rehabilitation progress early in the admission process.

A standardized six-item scale measuring a patient’s ability to perform basic activities of daily living independently. The Katz Index evaluates six functions—bathing, dressing, toileting, transferring, continence, and feeding—scoring each as independent or dependent. Developed in 1963, it remains one of the most widely used functional assessment tools in older adult and long-term care settings. The Katz Index provides a quick snapshot of functional status and is used in care planning, discharge decisions, and regulatory reporting. It is frequently administered alongside cognitive screening to provide a complete picture of a resident’s clinical needs.

An eight-item scale assessing competence in instrumental activities of daily living for community-dwelling and facility-based adults. The Lawton Instrumental Activities of Daily Living Scale evaluates eight functions: telephone use, shopping, food preparation, housekeeping, laundry, transportation, medication management, and financial management. Each item is scored on a three- or four-point scale. The Lawton Scale is particularly sensitive to early functional decline associated with mild cognitive impairment and is commonly used in long-term care and assisted living to determine the appropriate level of support and care planning.

Ongoing medical and personal care services for individuals who cannot perform daily activities independently over an extended period. Long-term care encompasses the medical, personal, and social services provided to individuals with chronic illnesses, disabilities, or cognitive impairment who require sustained assistance. LTC settings include skilled nursing facilities, assisted living, memory care, and home- and community-based services. LTC residents are among the most clinically complex populations in healthcare, with high rates of undiagnosed or under-screened cognitive, neurological, and behavioral health conditions. Automated screening technology addresses the screening gap by enabling routine, staff-free clinical assessment.

A specialized hospital for patients requiring extended acute care, typically with stays averaging 25+ days. Long-term acute care hospitals (LTACHs) serve medically complex patients who need extended hospital-level care—often involving ventilator weaning, wound care, or complex medical management. LTACH patients have average stays exceeding 25 days and frequently present with multiple comorbidities including cognitive and neurological conditions. Automated clinical screening technology is particularly valuable in LTACHs where patient acuity is high and clinical staff time is heavily allocated to acute medical needs.

A specialized residential care environment designed for individuals with Alzheimer’s disease, dementia, and other cognitive impairments. Memory care units or facilities provide a secure, structured environment with specialized programming for residents with Alzheimer’s disease, dementia, and other forms of cognitive impairment. Staff are trained in dementia-specific care techniques, and the physical environment is designed to reduce confusion and prevent elopement. Ongoing cognitive screening is critical in memory care to track disease progression, adjust care plans, and evaluate treatment efficacy. Speech biomarker technology enables longitudinal cognitive monitoring through natural conversation without requiring formal assessment sessions.

A brief three-minute cognitive screening combining a three-word recall test with a clock drawing task. The Mini-Cog is a rapid cognitive screening instrument that combines a three-item word recall with a clock drawing test. It takes approximately three minutes to administer and requires minimal training. The Mini-Cog is particularly useful in settings where time constraints limit the use of longer instruments like the MoCA. However, its brevity means reduced sensitivity for mild cognitive impairment. Speech biomarker technology provides an automated alternative that captures cognitive indicators from natural conversation without requiring explicit recall or drawing tasks.

A 30-point questionnaire used to measure cognitive impairment in clinical and research settings. The Mini-Mental State Examination (MMSE) tests orientation, registration, attention, recall, language, and visual construction. Developed in 1975, it remains widely used despite known ceiling effects and limited sensitivity to mild cognitive impairment. Administration takes 5–10 minutes and requires trained staff. Scores below 24 generally indicate cognitive impairment. Modern speech biomarker technology offers an automated alternative that can detect subtler cognitive changes without the floor and ceiling limitations of traditional instruments.

A widely used 30-point cognitive screening test for detecting mild cognitive impairment. The Montreal Cognitive Assessment (MoCA) evaluates visuospatial ability, executive function, naming, memory, attention, language, abstraction, delayed recall, and orientation. It takes approximately 10–15 minutes to administer and requires trained staff. A score below 26 suggests cognitive impairment. MoCA is considered more sensitive than the MMSE for detecting MCI. GIA® by Scienza Health offers an AI-powered alternative to MoCA, providing automated, real-time cognitive screening through speech biomarker analysis at peer-reviewed AUC 0.890 for cognitive decline—requiring only 40 seconds of natural conversation.

Clinical screening that simultaneously analyzes multiple data channels such as voice, facial expression, and language. Multimodal screening captures data from two or more sensory channels during a single patient encounter. In clinical applications, this typically means combining voice analysis (speech biomarkers), visual analysis (facial micro-expressions, body movement), and linguistic analysis (word choice, sentence structure) to produce a more comprehensive clinical picture. GIA® by Scienza Health uses multimodal screening to analyze 2,500+ speech biomarkers and 436 visual data points per session, increasing screening sensitivity across 35+ conditions.

Technology that automates the patient admission and screening process without requiring staff involvement. Patient intake automation replaces manual paper-based or staff-administered admission workflows with technology-driven processes. In post-acute and long-term care, this includes automating clinical screenings, collecting patient history, and documenting results in the EHR. GIA® by Scienza Health automates patient intake screening by conducting a natural conversation with the patient on a Samsung health-grade Galaxy device, analyzing 2,500+ speech biomarkers, and writing structured results back to the EHR—all without requiring any staff time.

A two-item ultra-brief depression screening derived from the first two questions of the PHQ-9. The PHQ-2 asks about the frequency of depressed mood and anhedonia (loss of interest) over the past two weeks. Scores range from 0–6, with a score of 3 or higher triggering full PHQ-9 administration. The PHQ-2 serves as an initial gate in stepped screening protocols. Its brevity makes it suitable for high-volume settings, though its sensitivity is lower than the full PHQ-9. Automated speech biomarker screening provides an alternative rapid screening method that captures objective vocal indicators of depression without relying on patient self-report.

A nine-item self-report questionnaire for screening, diagnosing, and monitoring depression severity. The PHQ-9 scores each of the nine DSM criteria for major depressive disorder on a 0–3 scale, producing a total score from 0–27. It is the most widely used depression screening tool in U.S. healthcare. Scores of 10 or higher indicate moderate depression warranting clinical follow-up. While effective, the PHQ-9 relies on patient self-report, which can be affected by stigma, insight, and cognitive impairment. GIA® by Scienza Health screens for depression using objective speech biomarkers at AUC 0.816 peer-reviewed accuracy, independent of patient self-report.

The leading cloud-based EHR platform for post-acute and long-term care facilities in North America. PointClickCare is the dominant electronic health record system in the U.S. skilled nursing facility market, serving thousands of long-term care, senior living, and home health organizations. It manages clinical documentation, billing, MDS reporting, and care coordination. GIA® by Scienza Health integrates directly with PointClickCare through HL7 FHIR and Direct API connections, enabling automated write-back of screening results, ICD-10 codes, and clinician notes to the patient record.

Healthcare services provided after discharge from an acute hospital stay, including rehabilitation, skilled nursing, and home health. Post-acute care (PAC) encompasses the continuum of services patients receive after an acute hospitalization: skilled nursing facilities, inpatient rehabilitation, long-term acute care hospitals, and home health agencies. PAC represents a significant portion of Medicare spending and is a key focus of quality improvement and cost-containment initiatives. Clinical screening at the point of PAC admission identifies conditions that may not have been detected during the acute stay, enabling more targeted care plans. GIA® by Scienza Health is purpose-built for the PAC environment.

The rhythm, stress, and intonation characteristics of speech that carry clinical information. Prosodic patterns describe the suprasegmental features of speech—how words are stressed, how sentences rise and fall in pitch, and how rhythm varies across an utterance. Flattened prosody (monotone speech) is associated with depression and Parkinson’s. Irregular prosodic patterns can indicate cognitive overload, anxiety, or early-stage dementia. GIA® by Scienza Health analyzes prosodic patterns as a core component of its speech biomarker technology, contributing to screening across cognitive, neurological, and behavioral health conditions.

Clinical screening that produces results during or immediately after the patient encounter. Real-time screening eliminates the delay between data collection and clinical interpretation. Rather than sending samples to a lab or scoring assessments after the visit, results are generated within seconds of the patient interaction. This is critical in post-acute and long-term care settings where timely intervention prevents adverse events. GIA® by Scienza Health delivers screening results to the clinician in under 2 minutes of the patient conversation, with findings written directly to the EHR.

Samsung’s defense-grade mobile security platform used to secure clinical devices in healthcare environments. Samsung Knox provides hardware-rooted security, device management, and compliance enforcement for Samsung Galaxy devices deployed in clinical settings. Knox enables remote device configuration, data encryption at rest and in transit, application whitelisting, and tamper detection. GIA® by Scienza Health comes pre-bundled on Samsung health-grade Galaxy devices secured with Samsung Knox, enabling facilities to deploy clinical screening in under 30 minutes without IT integration projects or software procurement.

A 30-point cognitive screening exam designed to detect mild cognitive impairment more sensitively than the MMSE. The Saint Louis University Mental Status (SLUMS) examination was developed specifically to address the MMSE’s limited sensitivity to mild cognitive impairment. It includes tasks for orientation, memory, attention, and executive function. SLUMS adjusts scoring thresholds based on education level. It takes approximately 7–10 minutes to administer. Like other traditional cognitive assessments, SLUMS requires trained staff and scheduled time—constraints that automated speech biomarker screening can help address in high-volume care settings.

A licensed facility providing 24-hour nursing care and rehabilitation services, typically following a hospital stay. Skilled nursing facilities (SNFs) provide round-the-clock nursing care, rehabilitation therapy, and medical oversight for patients who require a higher level of care than can be provided at home or in assisted living. SNFs are the primary care setting for post-acute rehabilitation and long-term care. They are heavily regulated by CMS and state agencies, with mandatory assessments (MDS), quality reporting, and survey compliance requirements. GIA® by Scienza Health is designed specifically for SNF deployment, automating clinical screening without adding to staff workload.

An auditing standard that evaluates a service provider’s controls for security, availability, processing integrity, confidentiality, and privacy. SOC 2 is an auditing framework developed by the AICPA that assesses whether a technology vendor’s systems and processes meet trust service criteria. A SOC 2 Type II report covers an extended observation period and provides assurance that controls are not only designed properly but operating effectively over time. Healthcare organizations increasingly require SOC 2 compliance from technology vendors handling patient data. Scienza Health maintains SOC 2 compliance for the digitalhumanOS™ platform.

The computational examination of spoken language to identify patterns with clinical significance. Speech analysis encompasses acoustic analysis (how someone sounds), prosodic analysis (rhythm, stress, intonation), and linguistic analysis (what words and structures are used). In clinical contexts, deviations from baseline speech patterns can indicate cognitive decline, depression, anxiety, movement disorders, and more. Peer-reviewed research from institutions including NIH, Harvard Medical School, and Mayo Clinic validates these associations. GIA® by Scienza Health applies multi-layer speech analysis to every 40-second patient conversation.

A measurable acoustic, prosodic, or linguistic feature of speech that correlates with a clinical condition. Speech biomarkers are quantifiable characteristics extracted from a patient’s voice—including pitch variability, speech rate, pause patterns, articulation precision, and lexical diversity. Clinically validated research demonstrates that these features can flag cognitive decline, depression, anxiety, PTSD, Parkinson’s, and other conditions. GIA® by Scienza Health analyzes over 2,500 speech biomarkers from just 40 seconds of natural conversation to generate real-time clinical screening results.

Detection and measurement of involuntary oscillations in the voice that may indicate neurological conditions. Vocal tremor analysis measures rhythmic fluctuations in pitch, amplitude, and articulatory control that are often imperceptible to the human ear. These tremors can be early indicators of Parkinson’s disease, essential tremor, tardive dyskinesia, and other movement disorders. Clinical research demonstrates that vocal tremor features detected through speech biomarker technology can flag these conditions earlier than traditional motor assessments. GIA® by Scienza Health includes vocal tremor analysis as part of its 2,500+ speech biomarker panel.

Technology that extracts clinical signals from acoustic properties of human speech. Voice analysis technology processes raw audio to extract features such as fundamental frequency, jitter, shimmer, harmonics-to-noise ratio, and formant transitions. In healthcare, these features serve as biomarkers that correlate with neurological, cognitive, and behavioral health conditions. Unlike subjective clinician assessment, voice analysis provides quantitative, reproducible measurements. GIA® by Scienza Health applies peer-reviewed voice analysis technology to screen for depression (AUC 0.816), PTSD (AUC 0.800), anxiety (AUC 0.775), and Parkinson’s (AUC 0.97).

The automated process of sending screening results from clinical technology directly into the patient’s EHR record. Write-back refers to the ability of a clinical system to push data into the EHR without manual re-entry. In screening workflows, write-back ensures that results, notes, transcripts, and codes are documented in the patient record immediately after the encounter. This is critical for regulatory compliance, continuity of care, and reducing clinician documentation burden. GIA® by Scienza Health writes four data types back to the EHR automatically: structured results with ICD-10 codes, clinician-ready notes, timestamped transcripts, and recorded video.

Clinical Decision Support

ADL (Activities of Daily Living)